期刊名称：Pakistan Journal of Analytical & Environmental Chemistry
印刷版ISSN：1996-918X
电子版ISSN：2221-5255
出版年度：2006
卷号：7
期号：2
页码：107-111
语种：English
出版社：National Centre of Excellence in Analytical Chemsitry
摘要：An analytical method has been developed using hanging mercury drop electrode (HMDE) for the quantitative determination of antibacterial drug cefadroxil (CFL) from pharmaceutical preparations and blood serum. Cathodic adsorptive stripping voltammetry was carried out in hydrochloric acid (0.1M): methanol (80: 20 v/v) and potassium chloride (0.1M) as supporting electrolyte. The reduction wave was obtained within -700 to -800 mV. Linear calibration curve was within 1-50µg/mL with detection limit of 0.1µg/mL of cefadroxil. Relative standard deviation for inter and intra day analysis of CFL was within 1-2%. The number of additives present in pharmaceutical preparations did not interfere the determination of cefadroxil. The analysis of pharmaceutical preparations and blood serum after chemotherapy with cefadroxil indicated relative standard deviation (RSD) within 0.8-1.2% and 2.6-3.8% respectively. The satisfactory results were obtained for quality control of cefadroxil in pharmaceutical preparations and in blood serum..
