标题：Irrational Abuse of Anabolic Steroids Stacking with Aromatase Inhibitors Increase Carotid Intima-Media Thickness (CIMT) and Lowering High Density Lipoprotein (HDL) levels Causing High Risk Factors for Cardiovascular Disease and Potential Steatohepatiti
期刊名称：International Journal of Applied Exercise Physiology
电子版ISSN：2322-3537
出版年度：2019
卷号：8
期号：3
页码：184-193
语种：English
出版社：Asian Exercise and Sport Science Association
摘要：Aim: Carotid intima-media thickness (CIMT) is an efficient predictor of cardiovascular risk and potential cardiovascular disease. The magical ability of abusing Aromatase Inhibitors (Tamoxifen Citrate and Anastrozole) in bodybuilding purposes is highly popular with the young recreational anabolic steroids abusers and especially those who will imbalance some primary side effects of anabolic steroids like water retention and enlarged breasts in men (gynecomastia). Potential cardiovascular and hepatic effects risk of the effects of 17 alpha-alkylated groups activated by anabolic steroids with Aromatase Inhibitor switch still remains hidden and investigated in our country and in most parts of the world. Material and methods: This short study was conducted from the beginning of August 2018 until the beginning march of 2019 at the Special Hospital dr. Solaković, Cardiovascular Surgery Clinic, Clinical Centre of University of Sarajevo, Sport Facultys of University of Sarajevo and East Sarajevo with internationally incorporated medical and sports scientists. Study included 120 male subjects of the age 17-30 (68 subjects who have aromatase inhibitors in their anabolic steroids cycles and impellers group consisting of 52 subjects who do not abuse aromatase inhibitors in their anabolic steroids cycles). Potential cardiovascular side effects of anabolic steroids in stacking with aromatase inhibitors are investigated. Non-parameter and parameter tests were used for the testing of statistical significance of differences between the examined groups. The difference at a level of p<0,001 was statistically significant. Results: Potential damage increase of cardiovascular and hepatic parameters after 8 months of study was confirmed in tested subjects sample (experimental group). Analysis shows no statistically significant influence of cardiovascular demographic damage in aromatase inhibitors group (p<0,001), compared to non_x005f?aromatase inhibitors abuser group (p<0,001). Conclusion: Anabolic steroid stacking has generally destructive cardiovascular and hepatic side effects. Young bodybuilding subjects who are involved in their steroid cycles of aromatase inhibitors increase the risk of cardiovascular disease and potential risk of liver disease.
