期刊名称：International Journal of Applied Exercise Physiology
电子版ISSN：2322-3537
出版年度：2019
卷号：8
期号：1
页码：138-148
DOI：10.30472/ijaep.v8i1.329
语种：English
出版社：Asian Exercise and Sport Science Association
摘要：Resistance training has beneficial impacts on the cardiovascular system and can be potentially useful for a variety of clinical conditions such as heart diseases. The current study aimed at investigating the effect of resistance training on serum levels of NT-proBNP, GDF-15, and markers of cardiac damage (CK and CK-MB) in the elderly males. In the current quasi-experimental study with pretest-posttest design, 24 males were selected from the elderly males population of Karaj city, Iran, with the mean age of 72.1 ± 5.3 years, height 164.3 ± 5.5 cm, and BMI 27.2 ± 4.3 kg/m2 and randomly divided into two groups of resistance training (n=12) and control (n=12). The exercise protocol was designed for eight weeks, three sessions per week with eight movements, each repeated 10 times. Data were analyzed by one-way ANOVA and post-hoc test. All analyses were performed with SPSS version 24 at a significance level of α = 0.05. Post hoc test results showed a significant decrease in NT-proBNP serum level after eight weeks of resistance training (P = 0.000). However, GDF-15 had no significant changes after exercise (P = 0.780). Post-test results indicated a significant increase in CK-MB level after eight weeks of resistance training (P = 0.000). Also, resistance training significantly increased CK serum level (P = 0.000). Resistance training significantly reduced NT-proBNP levels and significantly increased CK and CK-MB levels, but did not significantly alter GDF-15 levels in the elderly males. Therefore, investigating the role of NT-proBNP and GDF-15 biomarkers and also understanding the effect of resistance training mechanism on CK and CK-MB levels can provide valuable information about molecular processes affecting cardiac response of the elderly to resistance training, which results in a deep understanding of the mechanism and is the basis to conduct further studies in this field.
