出版社：National Research University Higher School of Economics (HSE)
摘要：Prostate cancer is one of the key causes of high cancer mortality in Russia and the world. In the absence of effective preventive measures, population-based screening using prostate-specific antigen (PSA) may be promising for mortality reduction. Despite conflicting results of randomized trials, the efficacy of prostate cancer screening in mortality reduction may be up to 30%. Overdiagnosis, typical for prostate cancer screening, limits a population-based implementation. Possible methods to decrease the amount of overdiagnosis and increase the effectiveness of population-based prostate cancer screening are discussed in a brief review of the literature. An analysis of selected results of randomized trials and a design for a new randomized trial are presented.
其他摘要：Рак предстательной железы – одна из ключевых причин высокой смертности от рака в России и мире. При отсутствии эффективных методов профилактики для снижения смертности может быть перспективен популяционный скрининг с помощью простатического специфическо
