期刊名称：Biosaintifika: Journal of Biology & Biology Education
印刷版ISSN：2085-191X
电子版ISSN：2338-7610
出版年度：2010
卷号：2
期号：1
页码：1-9
DOI：10.15294/biosaintifika.v2i1.1146
语种：English
出版社：Universitas Negeri Semarang
摘要：Carotenoids are important biological compounds in cancer prevention because they can inhibit the formation of free radicals, which react directly with oxygen. This research was aimed to determine the effect of antimutagenic â-carotene on 7.12-dimetilbenz(a) antracene (DMBA)-induced mice. From the observation of the mortality rate during the research period, the DMBA group showed the highest rate of mortality compared to the control group and the groups of â-carotene isolates. The incidence of tumors showed the declining trend in the groups of test animals that were given with the increasing doses of β-caroten isolate, i.e. 1.82; 3.64 and 7.28 mg kg-1 BW. The result may be caused by the increasingly high levels of â-carotene in the test solutions, resulting in the lower tissue damage and the inhibited growth of tumors in the lungs. Based on Kruskal-Wallis statistical analysis conducted on lung histology observational data for ten samples of each treatment group, it was confi rmed that there were signifi cant differences between treatments, which mean that â-carotene isolates can inhibit cancer growth in lung and skin of DMBA-induced animals.
