期刊名称：Biosaintifika: Journal of Biology & Biology Education
印刷版ISSN：2085-191X
电子版ISSN：2338-7610
出版年度：2014
卷号：6
期号：2
页码：117-127
DOI：10.15294/biosaintifika.v6i2.3778
语种：English
出版社：Universitas Negeri Semarang
摘要：Consuming lemuru oil and palm oil continuously could be expected to cause damage to the liver micro-anatomy. This study aimed to determine the micro-anatomy structure of liver and blood plasma total cholesterol level of white rats Wistar strain by post-oil supplementation of lemuru and palm oil. This research was experimental, with a completely randomized design. The research used 25 mice aged ± 3 months. Each was given a palm oil and lemuru oil as much as 0%+0%, 5%+5%, 10%+10%, 15%+15%, and 20%+20% orally for 28 days. Blood plasma levels of total cholesterol, body weight of rats and mice liver weight quantitatively analyzed using one-way ANOVA, with an error rate of 5%. The results showed that the palm oil and lemuru oil was toxic to the liver and decreased the blood plasma total cholesterol levels. Toxicological properties lemuru oil and palm oil to the liver can be seen from the change in the micro-anatomy structure of heart, liver macroscopic rat, and mouse liver weight. Micro-anatomy structural damage on liver cells were found in the form liver necrosis as well as the widening of the sinusoid. The conclusion of this study was the provision of palm oil and lemuru oil caused damage to microscopic liver cell necrosis form, thus affecting the macroscopic liver (changes in texture and color), a heavy heart, and affect the body weight of rats.
其他摘要：Mengkonsumsi minyak lemuru dan minyak sawit secara terus menerus, diduga dapat menyebabkan kerusakan mikroanatomi hati. Penelitian ini bertujuan untuk mengetahui struktur mikroanatomi hati dan kadar kolesterol total plasma darah tikus putih strain Wistar
