期刊名称：Ovidius University Annals, Series Physical Education and Sport/Science, Movement and Health
印刷版ISSN：1224-7359
出版年度：2012
卷号：12
期号：1
页码：84-88
语种：English
出版社：Ovidius University Press
摘要：The aim of the present study was to investigate the effects of testosterone on certain organs and the macro-anatomical changes induced by this hormone in pubescent male and female rats.The trial was conducted in 32 Sprague-Dawley rats,16 of which were male and 16 female,at the premises of the Experimental Animals Unit of Selçuk University,Faculty of Veterinary Medicine.The study protocol was approved by the Ethics Board of the same faculty.The male and female rats were allocated to two groups,one which constituted the control group and the other the experimental group.The average body weight of each animal was calculated.The experimental group was injected subcutaneously with 5 mg/kg of testosterone 5 days a week for a period of 10 weeks.At the end of the 10th week,the animals were euthanized;and their average body weight and the weight of the testes,liver,spleen,heart and kidneys were measured.The values of the group,which was administered with testosterone,were compared with those of the control group.The weight of the heart,right kidney,left kidney and spleen of male experimental and control rats did not differ from each other significantly (P>0.05).However,it was determined that testosterone administration led to a statistically significant reduction in the weight of the right and left testes and the liver (p<0.05) in male rats.In result,in the present study,it was demonstrated that testosterone caused certain morphometric changes in the organs of pubescent experimental rats.The results of the present study could be indicative of the effects of testosterone in young athletes,who use anabolic androgenic steroids.The results of the present study may contribute to raising awareness among athletes on the adverse effects of anabolic androgenic steroids.
