期刊名称：Ovidius University Annals, Series Physical Education and Sport/Science, Movement and Health
印刷版ISSN：1224-7359
出版年度：2013
卷号：13
期号：2
页码：784-788
语种：English
出版社：Ovidius University Press
摘要：Aim.In this study,it was aimed to investigate the effect of anabolic androgenic steroid nandrolone decanoate (ND) which commonly used for doping by sport players,on the relative weight of liver,spleen and gonads in male and female rats.Methods.For this purpose,60 rats (male =30,female =30) were used.Rats were divided into three groups as control group (0.5 mL 0.9% physiological saline,intraperiteonally (IP),peanut oil (PO) group (0.5 mL,IP) and ND group (10 mg/kg ND diluted in 0.5 mL peanut oil,IP).All injections were made daily for five days with a break for 2 days per week throughout the four weeks.The rats were euthanised at the end of the experiments and the relative weight of liver,spleen,testicle and ovaries were measured.Results.It was determined that relative weight of liver in male rats and the relative weight of spleen in both male and female rats in ND groups were lower than those in control group (p<0.05).Moreover,it was found that the administration of ND increased the relative weight of testicles as compared to control group (p<0.05).In conclusion,it is suggested that the decrement of relative weight of liver and spleen and the increment of relative weight of testicles may be an indicator for individual multiple organ failure and damage following long term administration of ND diluted in peanut oil.
