期刊名称：Ovidius University Annals, Series Physical Education and Sport/Science, Movement and Health
印刷版ISSN：1224-7359
出版年度：2016
卷号：16
期号：2
页码：564-569
语种：English
出版社：Ovidius University Press
摘要：Aim.CoQ10 (Ubiquinone-10) is a compound which serves as coenzyme in key enzymatic reactions during the energy production in the cell,may be found in each cell in different amounts,has the lipid structure and is similar to vitamin.Although it resembles vitamins in structure,it is not classified as vitamin due to the fact that it can be synthesized in the body.CoQ10 can be used as a protective and auxiliary substance in some diseases and treatment for its existence in all cells,having electron carrier feature in electron transport chain and strong antioxidant function.The CoQ10 deficiency are available in cases such as cardiac failure,angina pectoris,cardiomyopathy,hypertension,mitral valve prolapsus and atherosclerosis.CoQ10 supplement provides improvement in dilatation based on endothelium by regulating the vascular tonus.CoQ10 can prevent endothelial biomolecules from being damaged by inhibiting the lipid and protein peroxidation thanks to the antioxidant function,apart from the indirect effect on realization of vasodilatation.Moreover,It is reported that CoQ10 provides improvement in treatment of congestive cardiac failure,stroke volume,ejection fraction,cardiac output,cardiac index and diastolic volume index.Diastolic dysfunction is a myocardial insufficiency which constitutes the half of cardiac failure cases.In the studies about diastolic dysfunction,the results show that results show that CoQ10 may be administered as reliable,effective and complementary treatment method.Hypertension is the non-physiological elevation of systemic blood pressure.It is reported that action mechanism of CoQ10 in reducing the blood pressure occurs through the protection of NO concentration in endothelium.Further,it was noted that important improvements were observed following CoQ10 administration in patients having low extracellular SOD levels and high oxidative stress such as coronary artery diseases,and improvement in oxidative stress,decrease in peroxynitrite level,development in vasodilatation and decrease in myocardial damage were encountered.CoQ10 decreases blood viscosity in patients with ischemic cardiac disease and increases stream of blood into cardiac muscles.Conclusion.The studies suggest that CoQ10 supplements can be used as a safe and effective treatment method for cardiovascular diseases as ischemic cardiomyopathy,hypertensive,valvular heart disease,stroke volume,ejection fraction,cardiac output and diastolic dysfunction.
