期刊名称：Ovidius University Annals, Series Physical Education and Sport/Science, Movement and Health
印刷版ISSN：1224-7359
出版年度：2016
卷号：16
期号：2
页码：696-700
语种：English
出版社：Ovidius University Press
摘要：Objectives.In determining developing heart damage,Troponin I and cK-MB levels in the blood are measured.It has been determined that both signs of heart damage increase within 2-16 hours after damage occurs.Normal and high dose ibuprofen application’s effects on rats’ heart,blood counts,resistance to exercise and routine chemistry can be determined with the current research.Methods.Rats have been divided into four equal groups (control group,ibuprofen group,exhaustive exercise group,ibuprofen + exhaustive exercise group,N=24).80 mg/kg of ibuprofen has been given with gavage syringe to groups to which drug would be given and exhaustive exercise program has been applied to exercise group.All groups have been euthanized after 6 hours by taking blood from their hearts.Results.It has been determined in this study that ibuprofen application increases troponin I level (P<0.05) and ibuprofen + exercise application increases creatinine and BUN levels (P<0.05).It has been determined that troponin I which is the specific sign of heart damage is higher in ibuprafen group compared to exercise group.However,because of the reason that troponini I level of ibuprofen group is same as control group's level (P>0.05) and there is no difference in levels of CK-MB mass which is another sign of specific heart damage,this shows that ibuprofenin doesn't have heart damage-inducing effect.Conclusions.Consequently,it can be said that taking ibuprofen during exercise doesn't affect signs of heart damage but,it needs to be careful in terms of kidney damage.
