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  • 标题:Physicochemical characterization and in vitro dissolution behaviour of celecoxib-_-cyclodextrin inclusion complexes
  • 本地全文:下载
  • 作者:VIVEK RANJAN SINHA ; R. ANITHA1 SOMA GHOSH ; AMITA1 RACHANA KUMRIA
  • 期刊名称:Acta Pharmaceutica
  • 电子版ISSN:1846-9558
  • 出版年度:2007
  • 卷号:57
  • 期号:1
  • 页码:47-60
  • DOI:10.2478/v10007-007-0004-x
  • 语种:English
  • 出版社:Sciendo
  • 摘要:In this study,attempts were made to investigate the effects of -cyclodextrin (-CD) on the aqueous solubility and dissolution rate of celecoxib.Inclusion complexes were prepared by the kneading method and characterized by SEM,NMR,IR,DSC,and X-ray powder diffraction.Dissolution rate of the complexes was significantly greater than that of the corresponding physical mixtures and pure drug,indicating that the formation of inclusion complex increased the solubility of the poorly soluble drug celecoxib.
  • 关键词:celecoxib;-cyclodextrin;inclusion complex;dissolution profile
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