摘要：Celecoxib spherical agglomerates were prepared with polyvinylpyrrolidone (PVP) using acetone,water and chloroform as solvent,non-solvent and bridging liquid,respectively.The agglomerates were characterized by differential scanning calorimetry (DSC),X-ray diffraction (XRD),IR spectroscopic studies and scanning electron microscopy (SEM).The IR spectroscopy and DSC results indicated the absence of any interactions between drug and additives.XRD studies showed a decrease in crystallinity in agglomerates.The crystals exhibited significantly improved micromeritic properties compared to pure drug.The loading efficiency (% or mg drug per 100 mg crystals) was in the range of 93.9 ± 2.3 and 97.3 ± 1.3% (n = 3) with all formulations.The aqueous solubility and dissolution rate of the drug from crystals was significantly (p < 0.05) increased (nearly two times).The solubility and in vitro drug release rates increased with an increase in PVP concentration (from 2.5 to 10%).The SEM studies showed that the crystal posseses a good spherical shape with smooth and regular surface.
