标题：Synthesis and evaluation of the biological activities of some 3-_[5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl)- -1,3,4-oxadiazol-2-yl]-imino-1,3-dihydro-2H-indol-2-one derivatives
摘要：Reaction of ethyl-6-methyl–2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carboxylates (1a-i) with hydrazine hydrate yielded 6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carbohydrazides (2a-i).These products,on reaction with cyanogen bromide,gave 5-(5-amino-1,3,4- -oxadiazol-2-yl)-6-methyl-4-aryl-3,4-dihydropyrimidin-2 (1H)-ones (3a-i).The resultant aminooxadiazolylpyrimidinones were condensed with isatin to obtain various 3-_5-(6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin- -5-yl)-1,3,4-oxadiazol-2-yl-imino?-1,3-dihydro-2H-indol- -2-ones (4a-i).These products were characterized by IR,1H NMR,mass spectra and elemental analysis.Products (4a-i) revealed promising antibacterial,antifungal and antioxidant activity.
