摘要：A series of novel 3-cyclohexyl-2-substituted hydrazino- -quinazolin-4(3H)-ones were synthesized by reacting the amino group of 3-cyclohexyl-2-hydrazino quinazolin- -4(3H)-one with a variety of aldehydes and ketones.The starting material,3-cyclohexyl-2-hydrazino quinazolin- -4(3H)-one,was synthesized from cyclohexyl amine.Title compounds were investigated for analgesic,anti-inflammatory and ulcerogenic behavior.The compound 3-cyclohexyl-2-(1-methylbutylidene-hydrazino)-3H-quinazolin-4-one (4c) emerged as the most active compound of the series and is moderately more potent in its analgesic and anti-inflammatory activities compared to the reference standard diclofenac sodium.Interestingly,test compounds showed only mild ulcerogenic potential when compared to acetylsalicylic acid.
