摘要：New primaquine conjugates 5-7 with glucosamine and two polymers of polyaspartamide type,poly[a,b-(N-2-hydroxyethyl-DL-aspartamide)] (PHEA) and poly[a,b-(N- -3-hydroxypropyl-DL-aspartamide)] (PHPA),were synthesized,characterized and screened for their antimalarial activity.The conjugates differed in the type of covalent bonding,length of the spacer between the polymeric carrier and drug,molecular mass and drug-loading.Blood-schizontocidal activity of the prepared conjugates was tested against Plasmodium berghei infection in Swiss mice.Polymeric conjugates showed better antimalarial activity than the glucosamine conjugate.
