摘要：A series of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles 4a–j,5a–j and 6a–j has been synthesized and tested for their anti-inflammatory and anticonvulsant activities.Formation of the pyrazoloindole derivatives was achieved by treating arylhydrazones of N-alkyl indole-3-carboxaldehydes 1a–j,2a–j and 3a–j with ten times their mass of polyphosphoric acid as a condensing agent.The newly synthesized compounds were evaluated for their anti-inflammatory,analgesic and anticonvulsant activities compared to indomethacin,flufenamic acid and diazepam as positive controls.Detailed synthesis,spectroscopic and toxicity data are reported.
