摘要：A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration.The delivery system consisted of a loading- -dose tablet and a floating multiple matrix tablet prepared by the direct compression process.The drug release from biphasic GRDDS in 0.1 mol L–1 HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties.Stability studies showed no significant change in dissolution profiles (f2 value > 50).Based on the release kinetics,it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.
