摘要：3-[2-(4-Bromphenyl)hydrazono]-5-phenyl-furan-2(3H)-one (1) was used for preparation of some novel pyrazole,pyridazinone,oxadiazole,triazole,thiazolidine and thioxopyrimidine derivatives.Some of the prepared products were tested for anti-avian influenza virus activity and revealed promising antiviral activity against H5N1 virus [A/Chicken/Egypt/1/20 % (H5N1)] by determination of both EC50 and LD50 and confirmed by plaque reduction assay on Madin-Darby canine kidney cells.Compounds 3-[2-(4-bromophenyl)hydrazono]-5-phenylfuran- -2(3H)-one (1),1-(4-bromophenyl)-N-hydroxy-5-phenyl- -1H-pyrazole-3-carboxamide (5) and 1-(4-bromophenyl)- -N-{2,3-dihydro-4-hydroxy-3-phenyl-6-oxo-2-thioxopyrimidin-1(6H)-yl}-5-phenyl-1H-pyrazole-3-carboxamide (12a) showed the highest effects.Detailed synthesis,spectroscopic data,and antiviral activity of the synthesized compounds are reported.
