标题：Synthesis and characterization of some novel 1,2,4-triazoles,1,3,4-thiadiazoles and Schiff bases incorporating imidazole moiety as potential antimicrobial agents
摘要：(1,4,5-Triphenylimidazol-2-yl-thio)butyric acid hydrazide (3) was obtained via alkylation of 1,4,5-triphenylimidazol-2- thiol (1) with ethylbromobutyrate,followed by addition of hydrazine hydrate.Treatment of acid hydrazide 3 with carbon disulfi de in an ethanolic potassium hydroxide solution gave the intermediate potassium dithiocarbazinate salt,which was cyclized to 4-amino-5-[(1,4,5-triphenylimidazol- -2-yl)thiopropyl]-2H-1,2,4-triazole-3-thione (4) in the presence of hydrazine hydrate.Condensation of compound 3 with alkyl/arylisothiocyanate aff orded the corresponding 1-[4-(1,4,5-triphenylimidazol-2-ylthio)butanoyl]-4-alkyl/arylthiosemicarbazides (5–7),which upon refl uxing with sodium hydroxide,yielded the corresponding 1,2,4-triazole - -3-thiols 8–10.Under acidic conditions,compounds 4–6 were converted to aminothiadiazoles 11–13.Moreover,the series of Schiff bases 14–18 were synthesized from the condensation of compound 3 with diff erent aromatic aldehydes.The newly synthesized compounds were characterized by IR,1 H NMR,13C NMR and mass spectral analyses.They were also preliminarily screened for their antimicrobial activity.
