标题：Green ultrasound-assisted three-component click synthesis of novel 1H-1,2,3-triazole carrying benzothiazoles and fl uorinated- -1,2,4-triazole conjugates and their antimicrobial evaluation
摘要：The present study describes an effi cient and ecofriendly,ultrasound,one- pot click cycloaddition approach for the construction of a novel series of 1,4-disubstituted-1,2,3- triazoles tethered with fl uorinated 1,2,4-triazole-benzothiazole molecular conjugates.It involved three- component condensation of the appropriate bromoacetamide benzothiazole,sodium azide and 4-alkyl/aryl-5-(2- fluorophenyl)-3-(prop-2-ynylthio)-1,2,4-triazoles 4a-e through a Cu(I)-catalyzed 1,3-dipolar cycloaddition reaction.This approach involves in situ generation of azidoacetamide benzothiazole,followed by condensation with terminal alkynes in the presence of CuSO4/Na-ascorbate in aqueous DMSO under both conventional and ultrasound conditions.Some of the designed 1,2,3-triazole conjugates 6a-o were recognized for their antimicrobial activity against some bacterial and fungal pathogenic strains.
