摘要：The purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its effi cacy for overactive bladder (OAB) treatment.Patches were prepared using various polymers and plasticizers via the solvent casting method.The patches were characterized for tensile strength,thickness,moisture content,modulus of elasticity and water absorption capacity.Diff erential scanning calorimetry and Fourier transform infrared analyses were also performed.To determine patch eff ectiveness,in vitro release,permeation and animal studies were performed.The patches showed satisfactory percentage of release,up to 89.9 %,and their mechanical properties included thickness (0.10–0.15 mm),tensile strength (4.62–9.98 MPa) and modulus of elasticity (20–29 MPa).There were no signifi cant interactions between TT and other excipients.Animal studies indicated that the TT patch reduced the incidence of side eff ects;however,studies of longer duration are required to determine the eff ectiveness in treating OAB.
