摘要：Reactivity of 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene3-carbonitrile towards thioglycolic acid resulted in thiazole derivative 1.The latter reacted with different chemical reagents to give thiazole,pyrano[2,3-d]thiazole and thiazolo[4,5-d]thiazole derivatives.Cytotoxicity effects of the newly synthesized products against six cancer cell lines,namely,human gastric cancer (NUGC),human colon cancer (DLD1),human liver cancer (HA22T and HEPG-2),human breast cancer (MCF) and nasopharyngeal carcinoma (HONE-1) as well as against a normal fibroblast cell (WI-38) were evaluated.The study showed that the 4,5,6,7 tetrahydrobenzo[b] thiophene derivatives 6a,7,8a,b,9b and 10b,c were the most active compounds.Their potencies were attributed to the presence of the electron withdrawing groups.
