摘要：The aim of this study is to evaluate the antihyperalgesic and antinociceptive effects of two formulations containing peat water extracts using a model of carrageenan- -induced hyperalgesia,combined with a test with a mechanical stimulus,and a hot plate test.Rats were divided into seven groups (n = 6) and received local treatment with two peat formulations and two diclofenac formulations dissolved in carbopol gel and Wolff® basis creme,respectively.Carbopol gel,Wolff® basis creme and 0.9 % NaCl without tested substances were used as controls.Both peat formulations exerted an unambiguous antihyperalgesic effect 60 minutes after the treatment.In the hot plate test,the rats treated with the Wolff® basis creme peat formulation showed a tendency to prolonged latency on the first hour.The results could be explained by partial activation of peripheral α2-adrenoceptors and the possible COX-2 suppressive activity.
