摘要：In this study,we identified bioactive compounds from the ethanolic extracts of the leaves,stem bark and root bark of Acalypha wilkesiana through GC-MS analysis and investigated the effects of these extracts on some of the enzymes linked to type 2 diabetes.Plant parts were extracted sequentially with ethyl acetate,ethanol and water.GC-MS analysis revealed the presence of long-chain alkyl acids,esters,ketones and alcohols including phytol and phytol acetate along with some secondary metabolites such as xanthone,vitamin E and various types of sterols including stigmasterol,campesterol and sitosterol.Ethanolic extracts of all the parts showed a dose- -dependent inhibition of α-glucosidase and α-amylase activity.The extracts also demonstrated anti-lipase activity.The ethanolic extract of root bark showed the highest inhibition of enzymes compared to other extracts.The EC50 values (concentrations for 50 % inhibition) of α-glucosidase,α-amylase and lipase inhibition were 35.75 ± 1.95,6.25 ± 1.05 and 101.33 ± 5.21 µg mL–1,resp.The study suggests that A.wilkesiana ethanolic extracts have the ability to inhibit the activity of enzymes linked to type 2 diabetes.Further studies are needed to confirm the responsible bioactive compounds in this regard.
