摘要：Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a–f,primaquine bis-ureas 2a–f,chloroquine fumardiamides 3a–f and mefloquine fumardiamides 4a–f.Their antiproliferative activities against breast adenocarcinoma (MCF-7),lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro,using MTT cell proliferation assay.The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides,with IC50 values in low micromolar range against all tested cancer cell lines.
