摘要：Little is known about the pharmacological activities of Iris adriatica (Iridaceae),a plant endemic to Dalmatia (Croatia).We therefore performed a bioassay-guided fractionation including highperformance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc² 155.One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L–1.Furthermore,fractions were tested for resistance modulatory effects using ethidium bromide as substrate.We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly benzophenone 2,4,6-trihydroxy-4-methoxy-benzophenone,responsible for the resistance-modulatory activity of this plant.
