摘要：Post traumatic seizures induce structural and neurochemical changes in the Neural Stem cell (NSC) niches.The NSC niche shows a classic biphasic response to seizures.In the early weeks after a post traumatic seizure,there is an increase in neurogenesis.However,the integration of these new neurons into existing circuitry is defective leading on to epileptogenic circuits.As seizures continue,there is a decrease in neural proliferation,with consequences on cognition and mood.In this article,we explore the aetiopathogenesis of hippocampal epileptic circuitry and discuss conceptual and evolv ing therapeutic options.
