摘要：Emerging antibiotie resisance has created a major public health dilemma,compounded by a dearth of new antibiotic options.The development of antimicrobial resistance especially among gram-negative pathogens has been progressive and relentless.Pathogens of particular concern include extended-spectrum β-lactam ase- - producing Enterobacteriaceae,Carbapenem-resistant Enterobacteriaceae,multidrug-resistant Pseudomonas aeruginosa and multidrug-resistant.Acinetobacter spp.which are emerging as significant pathogens in various parts of the word.In some cases,these pathogens have expressed resistance to all clinically available compounds.Of the few new drugs available,many have already become targets for bacterial mechanisms of resistance.Furthermore,the Carbapenems,currently the most successful class of antibiotics are showing signs of vulnerability.While the search for new antibiotic options continues,there is urgent need to employ strategies that will slow the development of resistance to the current available armamentarium.A one year retrospective study from Jan 2011 to Dec 2011 was carried out at INHS Asvini to recognise the burden of multidrug-resistant gram-negative organisms in causing health care- -associated infections.Antimicrobial susceptibility patterns for all av ailable antibiotics classes were studied.Overall,14.3% of all gram negative isolates were multidrug-resistant gram negative bacilli (MDR-GNB).Of all the antimicrobial agents,the least efective was Ampicillin (88% resistance),while the most effective antibiotic against MDR-GNB were Imipenem (6% resistance),Meropenem (14% resistance) & Piperaillin-Tazobactam (20% resistance).However,a high degree of resistance among isolates w as found against Cephalosporins (35% - 40%).
