摘要:Presentation with intra-abdominal lymphadenopathy comes with a wide range of differentials,usually metastasis from regional organs,tuberculosis and lymphomas.But sometimes they surprise us with a histopathological diagnosis of Castleman's disease (CD).CD,also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia is a distinct form of lymphoproliferative disorder of uncertain origin that typically affects mediastinal or axillary lymph nodes.The present report describes a 30-year-old serving male who presented with pain abdomen and on and off episodes of melena,found to have peripancreatic lymphadenopathy on CECT abdomen.Ultrasound guided FNAC was done in private hospital revealed reactive lymphadenopathy.Excision biopsy was done in our institute and a diagnosis of Castleman's disease was made.