摘要：Aim : To study the outcome of psoriatic arthritis in a tertiary care hospital.Methodology : A Prospective observational study conducted at Department of Rheumatology and Department of Dermatology from 01 May 2014 - 30 June 2015.Data was collected from OPD register,admission and referral forms.All patients aged between 20-70 years,who had reported to these Departments and were willing in this study were enrolled.Inclusion criteria are the confirmed cases of Psoriasis with evidence of at least one joint involvement on clinical or radiological examination.Exclusion Criteria considered were Age < 20 years and >70 years,Rheumatoid factor,ANA positivity,HIV/HBsAg/HCV positivity,or any other evidence of Rheumatoid Arthritis.Patient suffering from Psoriatic arthritis who were meeting CASPER criteria were enrolled.They were screened by (Mantoux,Chest X ray,Serum Uric acid,VDRL,HBsAg,HIV,anti HCV antibody,Rheumatoid factor,and antinuclear antibody) for absence of other joint disease or evidence of connective tissue diseases that can affect joints or treatment.PASI score was calculated and they were started on NSAIDs.Except in Enthesitis Related Arthritis,all patients were started on Methotrexate and followed up on 3 monthly basis with clinical evaluation,Visual Analogue Scale and acute phase reactants.Cases who had failed to Methotrexate / NSAIDs after 3 months were started on BRM's and followed up.Results : Total psoriasis patient screened for athropathy were 120 patients in this study.Out of which 30 were detected to have psoriatic arthritis (PsA).Of these 30 PsA,03 were treated with NSAID and 27 were exhibited MTx.06 patients who had failed on MTx and were treated with Biological Response Modifiers (02 with infliximab and 4 with Etanercept).Two patients from enthesitis group who had refractory disease were treated with BRM (infliximab).Conclusion : Prevalence of Psoriatic arthritis in psoriasis in this study was 25%.Psoriasis being a common disease in general population,a high index of suspicion is kept in screening arthritis patients.Since the treatment for PsA is different from other joint diseases and reasonably well established,it should be started early for better patient satisfaction and to delay long term joint failure.
关键词：PsA- psoriatic Arthritis;GRAPPA : Group for Research and Assessment in Psoriasis and Psoriatic Arthritis;MTx- methotrexate;BRM : Biological Response Modifiers
