摘要：Background: Warts are mucocutaneous infections caused by human papillomavirus (HPV).Of the various modalities of treatment currently available,no single modality is uniformly efficacious and recurrences are common.Homologous autoimplantation is a minimally invasive procedure,which treats warts by stimulating a specific immune response against HPV.Aim: The aim of the study was to evaluate the clinical outcomes and recurrences after a single sitting of homologous autoimplantation therapy for multiple nonvenereal warts.Materials and Methods: Single homologous autoimplantation of wart tissue was done in 75 patients of multiple facial,palmoplantar,or common warts,reporting to a tertiary care dermatology center.They were assessed at 3 months for the outcome of the procedure,and those with complete clearance were followed up for 1 year for any recurrences.Results: Complete clearance was observed in 30 (40%) of the cases and 10 (13.3%) cases showed moderate clearance.In 13 (17.3%) cases,there was mild clearance,whereas 22 (29.3%) patients did not show any response to treatment.Patients with facial warts showed good therapeutic response with complete clearance seen in 62.5%,compared to plantar warts,where complete clearance was achieved only in 16%.At the end of the study period,recurrence was seen in only 1 (3.33%) patient in the complete clearance group.Conclusion: Autoimplantation therapy as a one time minimally invasive procedure has moderate efficacy in treating multiple warts with the best outcome being for facial warts.The virus-specific immunity generated in the process reduces the chances of recurrences.
