期刊名称：Computational and Structural Biotechnology Journal
印刷版ISSN：2001-0370
出版年度：2020
卷号：18
页码：2547-2555
DOI：10.1016/j.csbj.2020.09.010
出版社：Computational and Structural Biotechnology Journal
摘要：Discovery of antimicrobials in the past century represented one of the most important advances in public health. Unfortunately, the massive use of these compounds in medicine and other human activities has promoted the selection of pathogens that are resistant to one or several antibiotics. The current antibiotic crisis is creating an urgent need for research into new biological weapons with the ability to kill these superbugs. Although a proper solution requires this problem to be addressed in a variety of ways, the use of bacterial predators is emerging as an excellent strategy, especially when used as whole cell therapeutic agents, as a source of new antimicrobial agents by awakening silent metabolic pathways in axenic cultures, or as biocontrol agents. Moreover, studies on their prey are uncovering mechanisms of resistance that can be shared by pathogens, representing new targets for novel antimicrobial agents. In this review we discuss potential of the studies on predator-prey interaction to provide alternative solutions to the problem of antibiotic resistance.
关键词：Antibiotic crisis ; Bacterial predators ; BALOs ; Myxobacteria ; AR antibiotic resistance ; ARB antibiotic-resistant bacteria ; ARG antibiotic-resistant gene ; MDRB multi-drug resistant bacteria ; WHO World Health Organization ; HGT horizontal gene transfer ; SM secondary metabolite ; BALOs Bdellovibrio and like organisms ; OSMAC one strain many compounds ; BGC biosynthetic gene cluster ; NRPS nonribosomal peptide synthetase ; PKS polyketide synthase ; OMV outer membrane vesicle
