Three species of Brachyura crabs, Tyche emarginata White, 1847; Piloslambrus guerini (Brito Capello, 1871), and Hepatus scaber Holthuis, 1959, are recorded for first time in Colombian Caribbean Sea. Also, the distribution range of 20 previously recorded species is widened towards the north of the country. Samples were collected during INVEMAR-CORPOGUAJIRA cruise between March and April 2005 at the continental shelf (10 and 50 m depth) in La Guajira.