文章基本信息
- 标题：Induction of somatic mutations by low-dose X-rays: the challenge in recognizing radiation-induced events
- 本地全文：下载
- 作者：Haruki Nagashima ; Kumiko Shiraishi ; Saori Ohkawa 等
- 期刊名称：Journal of Radiation Research
- 印刷版ISSN：0449-3060
- 电子版ISSN：1349-9157
- 出版年度：2018
- 卷号：59
- 期号：suppl_2
- 页码：11-17
- DOI：10.1093/jrr/rrx053
- 摘要：It is difficult to distinguish radiation-induced events from spontaneous events during induction of stochastic effects, especially in the case of low-dose or low-dose-rate exposures. By using a hypersensitive system for detecting somatic mutations at the HPRT1 locus, we investigated the frequency and spectrum of mutations induced by low-dose X-rays. The mutant frequencies induced by doses of >0.15 Gy were statistically significant when compared with the spontaneous frequency, and a clear dose dependency was also observed for mutant frequencies at doses of >0.15 Gy. In contrast, mutant frequencies at doses of 0.2 Gy. Our observations suggest that there could be a critical dose for mutation induction at between 0.1 Gy and 0.2 Gy, where mutagenic events are induced by multiple DNA double-strand breaks (DSBs). These observations also suggest that low-dose radiation delivered at doses of <0.1 Gy may not result in DSB-induced mutations but may enhance spontaneous mutagenesis events. © The Author 2017. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology.
- 关键词：HPRT;low dose;mutations
