摘要：The frequency of chromatid breaks and the distribution of isochromatid breaks were measured in G2-phase normal human fibroblasts prematurely condensed a short time after exposure to low- or high-LET radiations. The average number of isochromatid breaks from a single particle traversal increased with increasing LET values, while the average number of chromatid-type breaks appeared to reach a plateau. The distribution of isochromatid breaks after high-LET iron particles exposure was overdispersed compared to γ-rays, indicating that a single iron particle traversal through a cell nucleus can produce multiple isochromatid breaks.
关键词：High-LET radiation; Premature chromosome condensation; Isochromatid break; Calyculin A
