标题：Cellular effect of thermal neutron capture treatment using 10B1-para-boronophenylalanine: Lethal effect on melanoma cells with different degrees of X-ray sensitivity.
摘要：We studied the effect of neutron capture treatment using 10 B-compound on X-ray sensitive P-39 and X-ray resistant G-361 human melanoma cell lines, and found a high lethal effect of boron neutron capture therapy in comparison with conventional ionizing radiation. The P-39 line was sensitive to thermal neutron radiation, and extremely sensitive to bleomycin treatment, whereas the G-361 line was resistant to both forms of treatment; however, the two cell lines had similar sensitivity to thermal neutron radiation after pretreatment with 10 B 1 -para-boronophenylalanine ( 10 B 1 -BPA, 200 μg/ml medium). These results show that the thermal neutron capture products (a 7 Li nucleus and alpha particle) are highly damaging and short range in tumor cells and thus more efficiently inactivate melanoma cells irrespective of x-ray sensitivity, than conventional X-ray-irradiation.
关键词：Thermal neutron capture therapy; 10 B 1 -para-boronophenylalanine; human melanoma cell; X-ray sensitive P-39 cells; X-ray resistant G-361 cells
