摘要：The effects of the restriction of food and water intakes on gastrointestinal absorption, distribution to organs and excretion of 131 I were investigated in C3H/He mice. The animals were divided into four groups and administered orally 37 kBq carrier-free Na 131 I in 0.25 ml normal saline. One group of animals was given food and water ad libitum throughout the experimental period. Food and water to the remaining groups were restricted before and/or after the administration of 131 I. The animals in each group were sacrificed 4 h and 24 h after administration, and the activity of 131 I in thyroid, blood, liver, kidney, gastrointestinal tract, urine, feces, and carcass was measured. There was a significant increase in the retention of 131 I in the thyroid and the concentration of 131 I in the blood due to the restriction of food and water after the administration of 131 I. In contrast, a significant decrease in the urinary excretion was observed in these animals. In those animals, which fasted before administration only, the retention of 131 I in the thyroid and other organs were decreased. Therefore, for an accurate diagnosis and effective therapy with radioiodine as well as effective radiation protection, the intake of food and water should be taken into account.
关键词：Radioiodine; Food and water restriction; Mice; Distribution; Retation
