摘要：The aims of present study are to estimate the biological risks to the immunity of mice exposed to heavy ion radiation and to investigate the effect of N -acetylcysteine (NAC) on 12 C 6 ion irradiation-induced lymphocyte DNA damage. Results showed that in the brine group, the levels of lymphocyte DNA damage and MN, thymocytes G 2 /M phase arrest and apoptosis percentages (except for activity of NK cells) were up at each time point. A time-response curve for MN and DNA damage appeared in the NAC group. We found that whole-body 12 C 6 ion irradiation at a dose of 4 Gy could: induce lymphocyte DNA double-strand breaks (DSBs); immunocytes DSBs may lead to acute effects on immunity; and 200 mg/kg NAC showed significant protection against radiation harm.
关键词：12C6 heavy ion;N-acetylcysteine;DNA double-strand breaks;Immunity acute effects
