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  • 标题:Low-dose Radiation Attenuates Chemical Mutagenesis In Vivo
  • 其他标题:Low-dose Radiation Attenuates Chemical Mutagenesis In Vivo
  • 本地全文:下载
  • 作者:Shizuko KAKINUMA ; Kazumi YAMAUCHI ; Yoshiko AMASAKI
  • 期刊名称:Journal of Radiation Research
  • 印刷版ISSN:0449-3060
  • 电子版ISSN:1349-9157
  • 出版年度:2009
  • 卷号:50
  • 期号:5
  • 页码:401-405
  • DOI:10.1269/jrr.09051
  • 摘要:The biological effects of low-dose radiation are not only of social concern but also of scientific interest. The radioadaptive response, which is defined as an increased radioresistance by prior exposure to low-dose radiation, has been extensively studied both in vitro and in vivo . Here we briefly review the radioadaptive response with respect to mutagenesis, survival rate, and carcinogenesis in vivo , and introduce our recent findings of cross adaptation in mouse thymic cells, that is, the suppressive effect of repeated low-dose radiation on mutation induction by the alkylating agent N -ethyl- N -nitrosourea. Translated and modified from Radiat. Biol. Res. Comm. Vol.43(4); 436-442, (2008, in Japanese).
  • 关键词:Low-dose radiation; Mutagenesis; Threshold; N -ethyl;N -nitrosourea
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