摘要:The purpose of this research was to develop the design of audio visual teaching materials to measure the creative thinking ability of biology students of FMIPA University of Bengkulu, based on research of lipolytic bacteria degrading palm oil liquid waste. The development model used is the 4D model (define, design, develop, disseminate). In the defining phase, an analysis of the depth of the material, from learning indicators in syllabus, units of lectures agenda and a great line of lesson plan. The analysis is also done by direct interviews to lecturers of microbiology subjects, and participate in learning activities both in the classroom and laboratory. The results of this material analysis serve as guidance in making the design of audio visual teaching materials. The next stage of activity is the design of the preparation of teaching materials developed from the existing learning syllabus. The design of audio visual teaching materials is carried out by feasibility measurement by media experts, IT experts and education practitioners. The results of the measurement of audio-visual material by media experts as 80%, by IT experts as 91.2%, and by education practitioners 75.2%. The deployment stage was only tested on 72 students of Biology Strata one math and science faculty University of Bengkulu, to see the level of creative thinking ability. Measurements to the level of creative thinking ability of students obtained a value of 12.5% in the high category, 70.8% medium category, and 16.7% low category.