标题：Effects of Branched-Chain Amino Acid and Glutamine Supplementation on Angiogenic Factors and Pro-Inflammatory Cytokines after Acute Exercise in Adolescence Athletes
摘要：The purpose of this study was to investigate the changes in the concentration of blood angiogenic factors and pro-inflammatory cytokines during acute exercise after the administration of branched-chain amino acid (BCAA) and glutamine. METHODS All 7 adolescent male athletes performed 2000 m rowing exercise after the completion of each of three different 7-day treatments; non-treatment (CO); a total daily dose of BCAA 3.15 g (1.05g×3) (BCAA); or both a total daily dose of BCAA 3.15 g (1.05 g × 3) and glutamine 6 g (2 g × 3) (BC GLU). There was a 30-day rest period between each treatment. After intake of amino acids for 7 days, the participants completed the rowing exercise on day 8, and their blood samples were collected (at resting state, Rest; immediately after exercise, Ex0; and 30 min after the exercise, Ex30) and were analyzed using ELISA. RESULTS The concentration of Vascular endothelial growth factor (VEGF) increased in the BCAA and BC GLU treatment groups compared to that at Rest in the CO group (p<0.05). Interleukin-6 (IL-6) increased at Ex0 compared to that at Rest in the CO and BCAA treatment groups (p<0.05), and significantly decreased at Ex30 compared to that at Ex0 in the BCAA treatment group (p<0.05). However, significant differences were not observed in BC GLU at Ex0 and Ex30 compared to at Rest. IL-8 also significantly increased at Ex0 compared to at Rest, and significantly decreased at Ex30 compared to at Ex0 in CO (p<0.05). However, the blood IL-8 level in BCAA and BC GLU were not altered by acute exercise. CONCLUSIONS This study suggested that the administrations of BCAA and/or glutamine have enough to induce increase of VEGF concentration and inhibited the increase of pro-inflammatory cytokines after acute exercise in adolescence athletes.
