期刊名称：RSF: The Russell Sage Foundation Journal of the Social Sciences
印刷版ISSN：2377-8253
电子版ISSN：2377-8261
出版年度：2018
卷号：4
期号：4
页码：137-149
DOI：10.7758/rsf.2018.4.4.08
出版社：Russell Sage Foundation
摘要：We interrogate state-level clustering of polygenic scores at different points in the life course and variation in the association of mean polygenic scores in a respondent's state of birth with corresponding phenotypes. The polygenic scores for height and smoking show the most state-level clustering (2 to 4 percent) with relatively little clustering observed for the other scores. However, even the small amounts of observed clustering are potentially meaningful. The state-mean polygenic score for educational attainment is strongly associated with an individual's educational attainment net of that person's polygenic score. The ecological clustering of polygenic scores may denote a new environmental factor in gene-environment research. We conclude by discussing possible mechanisms that underlie this association and the implications of our findings for social and genetic research.
