期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：14
页码：7548-7549
DOI：10.1073/pnas.2003876117
出版社：The National Academy of Sciences of the United States of America
摘要：When a cell replicates, genetic material must be duplicated, new proteins synthesized, and replication machinery built, all of which are critical processes that require delivery of sufficient building blocks and energy. In his Inaugural Article (1), Jens Nielsen, elected to the National Academy of Sciences in 2019, uses a quantitative “multiomics” approach in yeast to understand how metabolism is coordinated with the cell cycle. Analyzing the transcriptome, proteome, and metabolome of actively growing yeast, Saccharomyces cerevisiae, Nielsen, currently the CEO of BioInnovation Institute in Copenhagen, Denmark, has found that biosynthetic building blocks are synthesized on demand during the cell cycle. Jens Nielsen. Image courtesy of Jens Nielsen. > PNAS:Much of your recent work as a biochemical engineer has harnessed yeast as tiny factories for everything from alternative fuels to high-level production of fatty acids. What is it about yeast that makes it such a good organism for industrial uses? > Nielsen:We were interested to see if we could begin to produce jet fuel and also fuels for heavy trucks (2). They are hydrocarbons that need to have the right properties; they shouldn’t freeze up at very low temperatures.
> > We were quite successful in making yeast to produce the fatty acids (3, 4 …
