期刊名称：Proceedings of the National Academy of Sciences
印刷版ISSN：0027-8424
电子版ISSN：1091-6490
出版年度：2020
卷号：117
期号：14
页码：7573-7574
DOI：10.1073/pnas.2001049117
出版社：The National Academy of Sciences of the United States of America
摘要：We are pleased to read the Letter from Dr. Brewer (1) on our paper in PNAS (2). In our manuscript, we only briefly discuss our current knowledge about aldehyde dehydrogenase 2 (ALDH2) inhibition therapy for the treatment of alcohol user disorder (AUD) due to space limitation. We greatly appreciate Dr. Brewer for elaborating on previous findings in the area of ALDH2 inhibition therapies that were tested both in patients and in animal models (1). It is true that the effects of ALDH2 genotype on alcohol-seeking behavior have been well documented (3) and many drugs that … [↵][1]2To whom correspondence may be addressed. Email: bgao{at}mail.nih.gov. [1]: #xref-corresp-1-1
