This paper focuses on efficiently numerical investigation of two-dimensional heat conduction problems of material subjected to multiple moving Gaussian point heat sources. All heat sources are imposed on the inside of material and assumed to move along some specified straight lines or curves with time-dependent velocities. A simple but efficient moving mesh method, which continuously adjusts the two-dimensional mesh dimension by dimension upon the one-dimensional moving mesh partial differential equation with an appropriate monitor function of the temperature field, has been developed. The physical model problem is then solved on this adaptive moving mesh. Numerical experiments are presented to exhibit the capability of the proposed moving mesh algorithm to efficiently and accurately simulate the moving heat source problems. The transient heat conduction phenomena due to various parameters of the moving heat sources, including the number of heat sources and the types of motion, are well simulated and investigated.