摘要: Background Hypertrophic pyloric stenosis (HPS) is a common surgical condition in infancy, and typically presents at 2-4 weeks of age. Case Presentation A full term male neonate in Zeinabieh hospital, Shiraz, Iran was presented with oral feeding intolerance from birth, bile-stained output of nasogastric tube, and a double bubble sign on abdominal radiography suspected to duodenal atresia. However subsequent laparotomy on 3rd day of life revealed HPS. Conclusion This condition should be considered as part of a rare differential diagnosis of newborn with sign of obstruction at birth.