期刊名称：EKAIA Euskal Herriko Unibertsitateko Zientzi eta Teknologi Aldizkaria
印刷版ISSN：0214-9001
出版年度：2019
出版社：Euskal Herriko Unibertsitatea
摘要：In this review, we will explore the origin of the hypersensivity reactions which has become a major health problem with an increasing incidence in developed countries. For that aim, the main hypotheses of the hypersensitive reactions, the hygiene and microbiota hypotheses or Old Friend Mechanisms, are going to be explained. In the last years, the hygiene hypothesis has been replaced with the microbiota hypothesis due to diverse reasons, having an enormous importance the hygiene measures in the transmission of infectious diseases in high populations, and being misunderstood the hygiene concept. Also, the factors that influence in the hypersensitive reactions problems, such as the wrong use of antibiotics, the inappropriate diet or genetics factors, are going to be reviewed and discussed. In conclusion, the modernization process of the humanity, the inappropriate lifestyle and the excessive use of invasive medical practises have a negative effect in the microorganisms that are in contact with humans, increasing the incidence of hypersensitive reactions.
关键词：hypersensivity; hygiene hypothesis; microbiota hypothesis; Old friend mechanism; microbiota; dysbiosis; allergies origin;hipersentiberatasuna; higiene hipotesia; Old Friends; mikrobiotaren hipotesia; mikrobiota; disbiosia; alergien jatorria
