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  • 标题:Intervenções farmacológicas na degeneração corticobasal: uma revisão
  • 其他标题:Pharmacological interventions in corticobasal degeneration: a review
  • 本地全文:下载
  • 作者:Caixeta, Leonardo ; Caixeta, Victor de Melo ; Nogueira, Yanley Lucio
  • 期刊名称:Dementia & Neuropsychologia
  • 印刷版ISSN:1980-5764
  • 出版年度:2020
  • 卷号:14
  • 期号:3
  • 页码:243-247
  • DOI:10.1590/1980-57642020dn14-030006
  • 出版社:Associação de Neurologia Cognitiva e do Comportamento
  • 摘要:

    Corticobasal degeneration (CBD) is a sporadic tauopathy that presents with a varied combination of motor, cognitive, and behavioral features, making its diagnosis difficult. CBD has high morbidity and poor prognosis, with no effective therapy at present. We searched the PubMed/MEDLINE database for articles published from 1990 to 2019, using the keywords “corticobasal degeneration” AND “treatment.” The PRISMA method was adopted. Retrieved articles were characterized as having one of two methodological approaches: (1) studies aimed at primary tauopathy treatment and (2) symptomatic management. Review articles (based on CBD expert groups), case reports, case series, and pilot clinical trials were selected. Few attempts have been made to study drug options and drug efficacy in CBD systematically, and an effective treatment is not yet available. Treatment is symptomatic and based on similarity with other diseases due to the scarcity of studies specifically addressing CBD. CBD seems not to spark interest in more clinical trials for its low prevalence and reliability in clinical diagnosis.

  • 关键词:degeneração corticobasal;síndrome corticobasal;terapia dopaminérgica;tratamento
  • 其他关键词:corticobasal degeneration;corticobasal syndrome;dopaminergic therapy
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