摘要：Popular scientific summary We confirmed significant decreases in GGT and hs-CRP levels in male subjects suspected of non-alcoholic liver disease as a result of supplementation with 125 mg of GBCK25 (low dose). We found significant improvements in fatigue score with intake of 500 mg of GBCK25 (high dose). GBCK25 supplementation has beneficial effects on liver function. Background : Recently, clinical research has suggested that red ginseng components play a role in liver protection and combating fatigue. However, fermented ginseng has not been analyzed for liver-protective or anti-fatigue effects. Objective : This study evaluates the positive effects of fermented ginseng powder (GBCK25) on liver function. Methods : Ninety participants with elevated alanine aminotransferase levels (35 ≤ ALT ≤1 05 IU/L) were randomized to one of three groups. The participants were treated with GBCK25 tablets at a dose of 500 mg/day (high dose), 125 mg/day (low dose), or placebo group daily for 12 weeks. The primary outcomes included changes in ALT and gamma-glutamyl transferase (GGT) levels. The secondary outcomes included changes in aspartate amino-transferase (AST), high-sensitivity C-reactive protein (hs-CRP), multidimensional fatigue scale, lipid profile, and antioxidant markers. Results : In male subjects, after 12 weeks of low-dose GBCK25 (125 mg) supplementation, the GGT ( P = 0.036) and hs-CRP ( P = 0.021) levels decreased significantly more than those in the placebo group. High-dose GBCK25 (500 mg) supplementation significantly decreased the fatigue score compared with the placebo group. There were no clinically significant differences between the groups when studying any safety parameter. Conclusion : Our results suggest that GBCK25 supplementation has beneficial effects on liver function.
