Abstract The purpose of this paper is to explore the characteristics and potentialities of the cultural-mediatic analysis as a theoretical-methodological protocol of communication researches. In order to do this, we turn to Cultural Studies, especially to cultural analysis, to demonstrate possible appropriations of communication studies. We elucidate with applications and methodological tests in master’s degree dissertations, which found in this protocol a possibility to carry out research with critical depth and contextual density. As a contribution, this paper proposes to clarify a concept for cultural-mediatic analysis in order that such methodology becomes even more accessible and contributes to qualify the investigative process in the area of communication.